ea0065op1.2 | Adrenal and Cardiovascular | SFEBES2019
Urquijo Helena
, Panting Emma N
, Carter Roderick N
, Agnew Emma J
, Wyrwoll Caitlin S
, Morton Nicholas M
, Chapman Karen E
, Ivy Jessica R
Background: The late gestational surge in glucocorticoids is vital for the maturation of fetal organs in preparation for birth and survival during the neonatal period. Metabolic maturation of cardiomyocytes involves a switch in fuel substrate from glucose utilization to fatty acid (FA) oxidation. In fetal cardiomyocytes, glucocorticoids induce expression of Ppargc1a (encoding PGC1a, a master regulator of mitochondrial capacity). We hypothesized that glucocorticoids pr...